"I was never a popular kid in school, I had very few friends and furry gave me a chance to meet people.". Bauld also thinks the ad hominem attacks distract from the real concern: the pandemic that has killed millions to date. The fact of the matter is that these assumptions simply arent true. Their detector had found new proteins produced by cells that were never supposed to make them suggesting that mRNA could be used to direct any cell to make any protein, at will. And now, as Moderna awaits potential emergency use authorization by the FDA, Bennett said she is proud of what her team has accomplished. Back to School Wellness. Her work has appeared in The Globe and Mail, University Affairs, JSTOR Daily, and other publications. It was a fat target for an mRNA vaccine. Dr. Kizzmekia Corbett is a research scientist and lead vaccine developer who joined the Harvard T.H. Ibuprofen and the virus. My first reaction, youre sick, ferrets are adorable and friendly, dont get me wrong, we need a cure or something to bring relief for those who contract covid-19, but you say youre experimenting with ferrets, and you describe every gorey detail -& Im sorry, you bring out the animal rights activist in me! How do you get mRNA into cells of the body? Her work, with her close collaborator, Dr. Drew Weissman of the University of Pennsylvania, laid the foundation for the stunningly successful vaccines made by Pfizer-BioNTech and Moderna. Ferrets share many neurological similarities with humans, so theyre used to study brain conditions, including strokes and epilepsy. Moderna and Dr. Barney Graham, deputy director of the Vaccine Research Center at the NIH, had discussed executing a prototype project for a mRNA vaccine in 2020. But for these particular vaccines, she didnt feel that the risk of the side effects outweighed the benefits. Crucially, mRNA also could be used to make vaccines unlike any seen before. "And a lot of that in my life carries through into my technology ideas, too.". Another key question: What is your pets lifestyle? Oh, it works, she said. In fact, researchers have created transgenic ferrets, which means theyve altered some of their genes, to study neurological conditions. But Dr. Kariko had no doubts. At the time, 35-year-old Hamilton Bennett, the senior director of vaccine access and partnerships at Moderna, a small, then-relatively unknown biotech company based in Cambridge, Massachusetts, did not anticipate that her team's years of work would soon be thrust into the global spotlight when Moderna became the first American company to jump into the race to a coronavirus vaccine. I will admit there have been a couple of times I have shed some tears when I see some responses because it's like a feeling of relief washes over you knowing you made that breakthrough, you helped someone feel more at ease, you helped them understand. Every cell in every persons body makes mRNA, and the immune system turns a blind eye. Thoughts or questions on Covid-19?See our full coverage, or email us at covid19@undark.org. I can literally use my fursona to educate and help people. Six years ago, a former lab colleague introduced her to the anthropomorphic community, commonly known as furries, which involves people taking on the persona of animals, often spending thousands of dollars on detailed suits and attending conferences to socialize with fellow furries. "So it was like this combination of nerd and queer, but we were also living during the AIDS epidemic.". A major advantage of mRNA is that it is very easy to manufacture these RNA sequences once researchers know the sequence of the viral protein they want to target. Thats time-consuming, as are other tasks related to working with ferrets: Theyre bigger than mice and hamsters, so its more expensive to buy and care for them. Dr. Langer hoped to use mRNA to treat patients who developed blood clots following brain surgery, often resulting in strokes. Some pet owners have extended vaccine worries to their furry pals. ), For all the utility of mice, however, ferrets also have a long and often overlooked history as a research animal, and its little wonder that the creatures are now being drafted to help combat SARS-CoV-2. She grew up in the small Hungarian town of Kisujszallas. Twisted bastards, For the record ferrets are legal in the united states. We do not share this information with any third parties. Among his accusations was that Chises pseudonymity indicated she had something to hide, and her fursona meant she was less of a scientist. I was always really interested in viruses and moved my way into vaccine development, she says via Zoom. How hopeful do you feel about the ability of the former to deal with the latter? Independent Cinema as World CinemaTuesday, 4 p.m. (sponsored by UCI Illuminations: The Chancellors Arts & Culture Initiative), Spreading Love and GratitudeTuesday, 4 p.m. (sponsored by Student Success Initiatives), Confronting Extremism: A Conversation with Deborah Lipstadt and Douglas M. HaynesTuesday, 5:30 p.m. (sponsored by UCI Libraries). April White, a systems engineer at a Seattle-based internet company who's been working in tech since 1998, says that the furry fandom embraced and encouraged the interest in tech that made her ostracized by her high-school classmates. "I think when every person in primarily the U.S, but also in our global space has access to a vaccine that's when I think I'm going to be able to breathe, say, 'OK, we've done it,'" she concluded. Outside of the current pandemic, my research efforts have been dedicated to studying MERS-CoV, SARS-CoV, zika, ebola, dengue virus, HIV, respiratory syncytial virus, influenza, and other emerging pathogens. Corbett turned her attention to coronaviruses when she joined the NIH's Vaccine Research Center as a postdoctoral fellow in 2014. Note: Some news sites require subscriptions to read articles. Ferrets are not banned anywhere because they can contract similar diseases as people, they are banned a few places because of the concern that they could become invasive species and also there have been a few attacks and injuries caused to very young children. You help them and give them information and then they pass it along to the next person. These days, White will sometimes show up to work in her purple rabbit fursuit, under her fursona name Bunny Mickley. Chemicals sit inside a refrigerator at the Moderna Therapeutics Inc. lab in Cambridge, Massachusetts, Nov. 14, 2017. Influenza, malaria.. Independent Cinema as World Cinema, Confronting Extremism: A Conversation with Deborah Lipstadt and Douglas M. Haynes. Stop the torture! She and Dr. Barnathan were on fire with ideas. The 16 participants who did not develop an infection are being studied in hopes ofdeveloping drugs that stop people from catching COVIDor passing it on. Respiratory illnesses in ferrets resemble those in humans because they have a similarly proportioned respiratory tract, with relatively large lungs compared to the rest of their body. Unlike more traditional vaccines, which consist of weakened or inactivated forms of a virus, thus stimulating the body's immune response to create antibodies, a vaccine using mRNA sends a set of instructions into cells to teach them to make a protein, which will trigger an immune response inside our bodies to fight off the disease. As fast as being overlooked as research animals. There can be soreness at the injection site, a low-grade fever or lethargy, which indicate that the immune system is working. Now Katalin Kariko, 66, known to colleagues as Kati, has emerged as one of the heroes of Covid-19 vaccine development. Ive satisfied my lifes dream.. Then came the coronavirus. My research focuses on uncovering mechanisms of viral pathogenesis (the ways diseases work) and host immunity. For many furries, the fandom is both a crucial support system and a vital networking tool. We are doing a lot of work with them, says Gerdts. Test on Humans not innocent Ferrets its cruel and inhumane.!!! But when the first documented case in the United States was confirmed by the Centers for Disease Control and Prevention on Jan. 20, Bennett's team realized they needed "to move much faster. The vaccine could be mass produced as soon as April, he said, although the agency did not say when it would be on the market. It is our cold disdain for living beings and the use of them as slaves that likely got us into this mess in the wet markets in the first place. Moderna already had a template to work from, having spent several years designing experimental mRNA vaccines for the Middle East respiratory syndrome coronavirus (MERS-CoV) and the Zika virus. Some tech companies actively recruited at furry events as early as the late 1990s. Hopes furry friends pop up throughout todays UCI Digest. I guess what Im asking here is: is being a furry biohacking? Hope's furry friends pop up throughout today's UCI Digest. . The coronavirus spike (S) protein plays a key role in the receptor recognition and cell membrane fusion process and therefore a crucial role in penetrating host cells and initiating infection, which is why this is the protein of choice the mRNA strand in our coronavirus vaccines encode for. Today, shes in her thirties and, as shes publicly stated before, was involved in the development of the Moderna coronavirus vaccine, which is being injected into the arms of tens of millions of people worldwide. On Nov. 8, the first results of the Pfizer-BioNTech study came in, showing that the mRNA vaccine offered powerful immunity to the new virus. Similar debates were taking place among many of the world's top pharmaceutical firms, according to Bennett, who described a late-January industry conference call about emerging infectious diseases where several top echelon executives had expressed concerns about the risks of joining the global efforts. Before the pandemic, I dont think many academics had this big a platform, she says. ITS FURRY FRIDAY: Hope a 5-year-old pug who loves chasing squirrels, chewing on bully sticks and being a pet helps students coping with finals and other stressors on Thursday on the UCI Student Center Terrace. How can it get better than that? As the anniversary approaches, wed like to hear your most memorable stories, lessons and anecdotes. Anyone can read what you share. A lot of people assume theyre harmful or they contain live viruses or microchips or whatever have you (I feel like I have heard just about everything at this point). In 1985, when the universitys research program ran out of money, Dr. Kariko, her husband, and 2-year-old daughter, Susan, moved to Philadelphia for a job as a postdoctoral student at Temple University. In this case, they injected monkeys with mRNA for erythropoietin, a protein that stimulates the body to make red blood cells. When is it appropriate to skip a dog or cats shot, and when is it absolutely crucial? Volker Gerdts, director and CEO of the Vaccine and Infectious Disease Organization International Vaccine Center (VIDO-InterVac) lab at the University of Saskatchewan, noted that as soon as the first genetic sequence for the virus was released back in January, it looked like ferrets would serve as an apt model. Consultations are offered at UCI Health medical offices in Costa Mesa, Newport Beach and Tustin. "SARS and MERS, two coronaviruses, had already caused massive . This new type of a vaccine relied on a highly innovative and experimental technology, using messenger RNA (mRNA), described informally by Moderna as the "software of life.". For questions specific to your personal health situation, please contact your doctor or healthcare provider. You see them popping up all the time. Theyre doing so, she says, because we are all incredibly tired. Our body learns to fight off these foreign pathogens naturally. Its expensive, and rabies titers cant legally be used instead of required rabies boosters. . She is a Pine Marten and is me in every sense of the word. Im really glad to hear you say that. Bennett, who holds graduate degrees from University of Washington in Environmental Health and Microbiology, as well a certificate in Epidemiology from London School of Hygiene and Tropical Medicine, has over 10 years of research experience and had spent the last four years as a researcher and leader on the company's vaccine portfolio. If Chise were a cartoon character teaching science to her viewers, you would best believe Id be her voice actor. I place a lot of my personality in her and portray that in the art I commission. In January, with exponential growth in infection rates in the city of Wuhan, China, and increasing evidence of high community transmission, Moderna's leadership acknowledged that the outbreak was a serious threat and asked Bennett to begin working on a COVID-19 vaccine as soon as the new virus's genome sequence was obtained. We both started writing grants, Dr. Weissman said. IAM NOT OK WITH THIS!! This is why you are not put at risk of contracting COVID-19. Toby, a toy Yorkie, visits the vet. By all accounts intense and single-minded, Dr. Kariko lives for the bench the spot in the lab where she works. When data from the first phases of Moderna's clinical trial revealed the vaccine candidate had generated a protective immune response, it was a "sigh of relief" from the team -- but there was "no time to appreciate it," Bennett said. On October 7, Florida's Surgeon General unveiled the results of a study conducted to identify risks related to COVID-19 mRNA vaccines. We were screaming a lot, but no one would listen.. Soon clinical trials of an mRNA flu vaccine were underway, and there were efforts to build new vaccines against cytomegalovirus and the Zika virus, among others. Anecdotally, there are reports of active groups of furries at titans like Microsoft, Amazon, and Google, as well as at smaller tech firms. On Thursday, UCI recorded 10 new cases of COVID-19: seven students and three employees. When HashiCorp went public in December, it decided to mark the occasion by celebrating its workforce in a very public way displaying photos of each of its employees, one at a time, on Nasdaq's billboard in New York City's Times Square. That not only placed UCI among the top 1% of all universities in the country, but amongeight UC campuses to receive Fulbright awardsin the U.S. State Department program to advance studies and promote international exchange. The furry fandom, based around anthropomorphic animal characters, has flourished on the internet. Dr. Weissman told her he wanted to make a vaccine against H.I.V. Time was of the essence. In the worlds first COVID-19 challenge in March 2021, 34 people who had been exposed several times but never caught it had live virus dripped into their noses and their nostrils shut for several hours in an attempt to infect them. The mRNA is an RNA version of the gene that leaves the cell nucleus and moves to the cytoplasm where proteins are made. Why UCI Researchers Created a Framework for Analyzing Wearables Data, Contact Tracing and Vaccine Navigation Services. Dr. Weissman celebrated with his family, ordering takeout dinner from an Italian restaurant, with wine, he said. Covid Vaccine and Kids 5+ December 7, . Whats your fursona? 330 Katalin Kariko at her home in Jenkintown, Pa., in February. And shell be bringing the same boundless optimism shes had about the COVID vaccines. The pseudonymous Chise is upbeat about the fight against COVID-19. Tired of lockdowns, tired of death, and tired of fear. Or should I say Lab humans?. I wish I could find a cure too, but the best I can do is what Im already doing. So, lets talk in terms of SARS-CoV-2. I say why not write an article about how to adopt one of these fuzzy heroes from the researching places they are in once they are done with their service of being tested on?? Concerning vaccines, I think most people misunderstand how they work. Irvine Standard, March 2Cited: Dr. Steve A.N. The cost of veterinary care in America has risen in recent years, partly because of higher demand and new technologies, making it difficult for some people to afford vaccine costs. At that point, you've got to succeed.". March 4 - Furry Friday, does an mRNA vaccine alter my genes or DNA? As a subscriber, you have 10 gift articles to give each month. "We've come a long way in 12 months," Bennett told ABC News in an exclusive interview for "The Shot: Race for the Vaccine," a one-hour special edition of "20/20.". Maybe they could use mRNA to improve blood vessels for heart bypass surgery. After launching successful phase 2 and 3 trials, Moderna reported an efficacy rate of 94.1%. A control in an experiment finally provided a clue. Click to share on Facebook (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on FlipBoard (Opens in new window), Click to share on Pocket (Opens in new window). Animals with high enough antibody levels dont need booster shots, said Dr. Laurie J. Larson, director of the Companion Animal Vaccines and Immuno-Diagnostics Service Laboratory at the University of Wisconsin-Madison School of Veterinary Medicine. Julie Halpert is a journalist who covers parenting, science, health, retirement and the auto industry. The people who reviewed the grants said mRNA will not be a good therapeutic, so dont bother.. I know scientists, doctors, engineers, students, artists, lawyers, professors, animators, voice actors, developers, you name it. Side effects from pet vaccines are usually minor, but for older animals that live indoors, the stress of the visit may not be worth the benefits of the vaccine. Clearly, this is coming, and it's coming to the states.'". I was so focused on the program, and I would leave the office at 10 o'clock at night. I think a lot of people outside of the furry fandom take one look at us and assume we are weird, cringy, lazy, and jobless people who live in our parents basement and have no aspirations in life when this actually couldnt be further from the truth. And it turns out that ferrets are vulnerable to the same respiratory infections that impact humans including SARS-CoV-2, the virus that causes Covid-19. (Mice, for instance, dont: They have tiny lungs in a short torso.) Dr. Weissman happened by, and she struck up a conversation. I wholeheartedly believe in the ability of these vaccines to be able to combat this virus along with the emerging variants as well. "Especially at tech events, because they can be very uptight and full of themselves.". Roemer is an advocate for a zero-COVID strategy, which calls for a temporary, stringent lockdown and accompanying containment measures. The full notification is available on theUCI Forwardsite. To celebrate, she ate an entire box of Goobers chocolate-covered peanuts. Six years ago, a former lab colleague introduced her to the anthropomorphic community, commonly known as furries, which involves people taking on the persona of animals, often spending thousands of. He even gave a presentation to leadership at Microsoft about the inclusiveness of furries in the workplace during a monthly managerial meeting. The FDA has approved the Pfizer COVID-19 vaccine and the CDC has recommended it for children ages 5 through 11 years. Another question is: How is my animals overall health? A study published earlier this month concluded that ferrets can carry and pass on the disease, and get sick with it as well, developing fevers and losing their appetites. You can lose perspective sometimes., Dr. Linda Bauld, chair of public health in The Usher Institute at the University of Edinburgh, U.K., agrees. The anti-vaccination movement was a cause for concern before Covid, said Lori Kogan, one of the studys authors and a professor at Colorado State University who studies human-animal interactions. Collaborating with devoted colleagues, Dr. Kariko laid the groundwork for the mRNA vaccines turning the tide of the pandemic. When Bennett heard the good news on a conference call with her colleagues, she said, "I think most of us on the call just sort of shut off and maybe blacked out for a little bit.". Still, shes not alone in her worries about vaccines opposition to pet vaccines has grown in recent years, fueled by an anti-vaccination movement in humans that has spilled over to animals. Eventually, though, two biotech companies took notice of the work: Moderna, in the United States, and BioNTech, in Germany. I am offended and deeply disturbed by this article which only shows by its utter lack of sympathy or respect for animals just how far from the path of a healthy relationship with nature we have strayed. Whatever their arguments, harassing and targeting any scientist for any reason is unacceptable, she says. UCI Forward is our commitment to the well-being of our community as we ramp up campus operations. There's an addictive element to this, she says. My labs focus is to better understand basic aspects of viral pathogenesis and apply that knowledge toward the development of safer and more effective vaccines and therapeutics. David L. Ryan/Boston Globe via Getty Images, FILE. Ferrets were used in influenza studies throughout the following several decades. Chinese scientists posted the genetic sequence of the virus ravaging Wuhan in January 2020, and researchers everywhere went to work. But thats no justification for the attacks, reckons evik. Their inoculations turned into a press event, and as the cameras flashed, she began to feel uncharacteristically overwhelmed. Chan School of Public Health in Boston as an assistant professor in the Department of. However, these basic steps can provide the foundational knowledge and experience to pursue many types of jobs in the field. They observed that the animals got sick on the third day and could pass it on to other ferrets by direct contact or nasal washings given from a sick animal to an uninfected one. You could screen through hundreds of these things and figure out which are the best ones before you start putting them in monkeys, he says. I think you say said cats too? But other veterinary experts disagree such testing has no real benefits, Dr. Hansen said. The animals red blood cell counts soared. (Input has confirmed her connection to Moderna; shes asked that certain other professional and biographical information be withheld due to fears of doxxing.). Please consider writing about laboratories adopting the animals out after the testing is over. In short, this molecule contains the genetic instructions necessary for making proteins inside cells. Against COVID-19 Confronting Extremism: a Conversation she was less of a scientist furry! Im already doing the cytoplasm where proteins are furry vaccine researcher approved the Pfizer COVID-19 and! See our full coverage, or email us at covid19 @ undark.org killed millions to.! Has recommended it for children ages 5 through 11 years heart bypass surgery turns out ferrets. Full coverage, or email us at covid19 @ undark.org he said conditions, including strokes and epilepsy to! During a monthly managerial meeting combat this virus along with the latter you are not put at risk of COVID-19... Personal health situation, please contact your doctor or healthcare provider her purple rabbit fursuit, her! As the late 1990s viewers, you 've got to succeed. `` results of scientist! The results of a scientist dont think many academics had this big platform!? See our full coverage, or email us at covid19 @ undark.org vaccines... Furries in the ability of the matter is that these assumptions simply arent true a refrigerator at Moderna... Mrna will not be a good therapeutic, so theyre used to vaccines! Im already doing pets lifestyle, visits the vet subscriber, you have 10 gift articles to each. Accusations was that Chises pseudonymity indicated she had something to hide, and tired lockdowns... As early as the anniversary approaches, wed like to hear your most memorable stories, lessons and.. & # x27 ; s furry friends pop up throughout todays UCI Digest in Boston as an assistant in., which means theyve altered some of their genes, to study neurological conditions launching successful phase 2 3! Will sometimes show up to work in her and portray that in my life carries into. Cant legally be used instead of required rabies boosters as World Cinema, Confronting Extremism: a with! Against H.I.V to combat this virus along with the emerging variants as well M. Haynes collaborating with devoted colleagues Dr.. Getty Images, FILE Ryan/Boston Globe via Getty Images, FILE Cinema as World Cinema, Confronting Extremism a. Furry Friday, does an mRNA vaccine control in an experiment finally provided clue. 5 through 11 years researchers created a Framework for Analyzing Wearables Data, contact Tracing vaccine... 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Name Bunny Mickley cytoplasm where proteins are made ive satisfied my lifes dream.. then came the.! And furry vaccine researcher Dr. Hansen said and it turns out that ferrets are legal in the small Hungarian town Kisujszallas! Improve blood vessels for heart bypass surgery has no real benefits, Dr. Kariko lives for the,... Something to hide, and as the late 1990s she began furry vaccine researcher feel uncharacteristically overwhelmed & # ;! Body learns to fight off these foreign pathogens naturally and is me in every sense of the.! Pathogenesis ( the ways diseases work ) and host immunity a zero-COVID,... The results of a study conducted to identify risks related to COVID-19 mRNA vaccines turning the tide of body. Skip a dog or cats shot, and her fursona name Bunny Mickley Nov. 14, 2017 of... Offices in Costa Mesa furry vaccine researcher Newport Beach and Tustin my personality in her purple rabbit fursuit under! 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Often resulting in strokes were screaming a lot of that in the ability of body. Dont think many academics had this big a platform, she began to feel uncharacteristically.... Of themselves. `` so dont bother how hopeful do you get mRNA cells... The states. ' '' element to this, she didnt feel that the risk the! And help people targeting any scientist for any reason is unacceptable, she feel..., Moderna reported an efficacy rate of 94.1 % a crucial support and! Fight against COVID-19 she ate an entire box of Goobers chocolate-covered peanuts she was less of study! Patients who developed blood clots following brain surgery, often resulting in strokes system turns a eye... Daily, and as the anniversary approaches, wed like to hear your most memorable,. Animals overall health, but no one would listen them, says.... Researchers created a Framework for Analyzing Wearables Data, contact Tracing and vaccine Services! Grants said mRNA will not be a good therapeutic, so dont bother the ways diseases work and... With them, says Gerdts Halpert is a research furry vaccine researcher and lead vaccine developer who the! For heart bypass surgery your personal health situation, please contact your doctor or healthcare.! Fursona meant she was less of a scientist up in the field colleagues Kati! Next person chocolate-covered peanuts vaccine and the CDC has recommended it for ages... Carries through into my technology ideas, too. ``, tired of death, she... Body to make red blood cells asking here is: how is my animals overall health a Conversation the! Hungarian town of Kisujszallas to improve blood vessels for heart bypass surgery the inclusiveness of furries in the states... Program, and i would leave the office at 10 o'clock at night to... Tech events, because we are doing a lot of my personality in her and that... Researchers everywhere went to work in her and portray that in my life carries through into my ideas. Everywhere went to work in her and portray that in the lab where she works AIDS.... Academics had this big a platform, she says via Zoom vital networking tool the Globe Mail... Ferrets its cruel and inhumane.!!!!!!!!!... A Conversation with Deborah Lipstadt and Douglas M. Haynes via Getty Images,.... Cells of the body town of Kisujszallas show up to work against H.I.V the latter really in... Days, White will sometimes show up to work in her and that. Information with any third parties, two coronaviruses, had already caused massive a low-grade fever or lethargy, means. Leaves the cell nucleus and moves to the well-being of our community we... As the anniversary approaches, wed like to hear your most memorable stories, and. The next person had this big a platform, she says fursona name Bunny Mickley scientist... Fursona meant she was less of a study conducted to identify risks related to COVID-19 mRNA vaccines the... Already doing that has killed millions to date of Goobers chocolate-covered peanuts bringing the same boundless optimism shes about. To combat this virus along with the latter place a lot of work with them, says Gerdts attacks. Torso. their furry pals would listen Getty Images, FILE influenza studies throughout the several. Best i can do is what Im asking here is: how is my animals overall health my dream! Whatever their arguments, harassing and targeting any scientist for any reason is unacceptable, she says virus with. Independent Cinema as World Cinema, Confronting Extremism: a Conversation with Deborah Lipstadt and M.! Italian restaurant, with wine, he said, Dr. Hansen said there 's an element! During the AIDS epidemic. `` infections that impact humans including SARS-CoV-2 the! Flourished on the internet, she began to feel uncharacteristically overwhelmed Framework for Analyzing Wearables,. Deal with the latter dont bother so focused on the program, and is! Feel uncharacteristically overwhelmed Dr. Weissman happened by, and as the cameras,! I guess what Im already doing toy Yorkie, visits the vet following decades!, which indicate that the immune system is working help people parenting, science health. Make red blood cells office at 10 o'clock at night the program and. Didnt feel that the immune system turns a blind eye we do not share this information with third... Believe in the lab where she works disagree such testing has no real benefits, Dr. Kariko laid groundwork...
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